Souza was born in Mexico City to a Chilean father and Mexican mother. She lived in Aspen, Colorado until she was eight years old. She studied acting at Centro de Educación Artística, the famed acting school run by Mexican media giant, Televisa, in Mexico City. She also attended acting school in France and completed an intensive summer acting course in Moscow, Russia. In 2008, she completed a Bachelor of Arts in Acting at Central School of Speech and Drama in London. At 22, she returned to Mexico City and began acting in television and film.
In 2009, Souza debuted in the Mexican telenovela Verano de amor, starring singer Dulce Maria, and later starred in Mexican sitcoms Los Héroes del Norte and La Clinica. Her film roles include From Prada, to Nada; in 2013, and two Mexican box office hits, Nosotros los Nobles and Instructions Not Included.